Effects of 1,4-phenylenebis(methylene)selenocyanate on mutagenesis and p53 protein expression in the tongue of lacI rats treated with 4-nitroquinoline-N-oxide

Previously we showed that the organoselenium compound, 1,4-phenylenebis(methylene)selenocyanate (p-XSC) inhibits 4-nitroquinoline-N-oxide (4-NQO)-induced tongue tumorigenesis in Fisher rats. Here we investigate possible mechanisms of this inhibition by monitoring mutagenesis and p53 protein levels i...

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Bibliografiska uppgifter
Huvudupphovsmän: Guttenplan, Joseph, Chen, Kun-Ming, Khmelnitsky, Michael, Kosinska, Wieslawa, Hennessy, Jeanine, Bruggeman, Richard, Desai, Dhimant, Amin, Shantu, Sun, Yuan-Wan, Spratt, Tomas, El-Bayoumy, Karam
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2007
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2700054/
https://ncbi.nlm.nih.gov/pubmed/17720616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mrgentox.2007.07.005
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