Dysregulation of endocytic machinery and ACE2 in small airways of smokers and COPD patients can augment their susceptibility to SARS-CoV-2 (COVID-19) infections

Lungs of smokers and chronic obstructive pulmonary disease (COPD) are severely compromised and are susceptible to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) attack. The dangerous combination of enhanced SARS-CoV-2 attachment receptor protein ACE2 along with an increase in endocytic...

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Detalhes bibliográficos
Publicado no:Am J Physiol Lung Cell Mol Physiol
Main Authors: Eapen, Mathew Suji, Lu, Wenying, Hackett, Tillie L., Singhera, Gurpreet Kaur, Thompson, Isobel E., McAlinden, Kielan Darcy, Hardikar, Ashutosh, Weber, Heinrich C., Haug, Greg, Wark, Peter A. B., Chia, Collin, Sohal, Sukhwinder Singh
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2021
Assuntos:
Rapid Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7869956/
https://ncbi.nlm.nih.gov/pubmed/33174446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00437.2020
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