Dysregulation of endocytic machinery and ACE2 in small airways of smokers and COPD patients can augment their susceptibility to SARS-CoV-2 (COVID-19) infections

Lungs of smokers and chronic obstructive pulmonary disease (COPD) are severely compromised and are susceptible to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) attack. The dangerous combination of enhanced SARS-CoV-2 attachment receptor protein ACE2 along with an increase in endocytic...

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Опубликовано в: :Am J Physiol Lung Cell Mol Physiol
Главные авторы: Eapen, Mathew Suji, Lu, Wenying, Hackett, Tillie L., Singhera, Gurpreet Kaur, Thompson, Isobel E., McAlinden, Kielan Darcy, Hardikar, Ashutosh, Weber, Heinrich C., Haug, Greg, Wark, Peter A. B., Chia, Collin, Sohal, Sukhwinder Singh
Формат: Artigo
Язык:Inglês
Опубликовано: American Physiological Society 2021
Предметы:
Rapid Report
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7869956/
https://ncbi.nlm.nih.gov/pubmed/33174446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00437.2020
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