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DDB2 regulates DNA replication through PCNA-independent degradation of CDT2
BACKGROUND: Targeting ubiquitin-dependent proteolysis is one of the strategies in cancer therapy. CRL(CDT2) and CRL(DDB2) are two key E3 ubiquitin ligases involved in DNA replication and DNA damage repair. But CDT2 and DDB2 are opposite prognostic factors in kinds of cancers, and the underlining mec...
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| Udgivet i: | Cell Biosci |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
BioMed Central
2021
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7869461/ https://ncbi.nlm.nih.gov/pubmed/33557942 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13578-021-00540-5 |
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