DDB2 regulates DNA replication through PCNA-independent degradation of CDT2

BACKGROUND: Targeting ubiquitin-dependent proteolysis is one of the strategies in cancer therapy. CRL(CDT2) and CRL(DDB2) are two key E3 ubiquitin ligases involved in DNA replication and DNA damage repair. But CDT2 and DDB2 are opposite prognostic factors in kinds of cancers, and the underlining mec...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Cell Biosci
Päätekijät: Wu, Xiaojun, Yu, Min, Zhang, Zhuxia, Leng, Feng, Ma, Yue, Xie, Ni, Lu, Fei
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: BioMed Central 2021
Aiheet:
Research
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7869461/
https://ncbi.nlm.nih.gov/pubmed/33557942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13578-021-00540-5
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