Exploitation of the vitamin A/retinoic acid axis depletes ALDH1-positive cancer stem cells and re-sensitises resistant non-small cell lung cancer cells to cisplatin

• All-trans retinoic acid (ATRA) and retinol significantly reduced ALDH1+ve cell subsets. • Co-treatment of ATRA or retinol with cisplatin significantly inhibited NSCLC cell survival. • Retinoic acid pathway inhibition induced apoptosis of chemo-resistant cells. • RAR and RXR nuclear receptors were...

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Publicat a:Transl Oncol
Autors principals: MacDonagh, Lauren, Santiago, Rhyla Mae, Gray, Steven G., Breen, Eamon, Cuffe, Sinead, Finn, Stephen P., O'Byrne, Kenneth J., Barr, Martin P.
Format: Artigo
Idioma:Inglês
Publicat: Neoplasia Press 2021
Matèries:
Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7868629/
https://ncbi.nlm.nih.gov/pubmed/33550205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tranon.2021.101025
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