The mTORC1 complex in pre-osteoblasts regulates whole-body energy metabolism independently of osteocalcin

Overnutrition causes hyperactivation of mTORC1-dependent negative feedback loops leading to the downregulation of insulin signaling and development of insulin resistance. In osteoblasts (OBs), insulin signaling plays a crucial role in the control of systemic glucose homeostasis. We utilized mice wit...

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Vydáno v:Bone Res
Hlavní autoři: Tangseefa, Pawanrat, Martin, Sally K., Chin, Peck Yin, Breen, James, Mah, Chui Yan, Baldock, Paul A., Wittert, Gary A., Page, Amanda J., Proud, Christopher G., Fitter, Stephen, Zannettino, Andrew C. W.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7868369/
https://ncbi.nlm.nih.gov/pubmed/33551450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41413-020-00123-z
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