In Vitro and In Vivo Antitumor Activity of Indolo[2,3-b] Quinolines, Natural Product Analogs from Neocryptolepine Alkaloid

Neocryptolepine (5-methyl-5H-indolo[2,3-b] quinoline) analogs were synthesized and evaluated in vitro and in vivo for their effect versus Ehrlich ascites carcinoma (EAC). The analogs showed stronger cytotoxic activity against EAC cells than the reference drug. The in vivo evaluation of the target co...

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Bibliographic Details
Published in:Molecules
Main Authors: Altwaijry, Najla, El-Ghlban, Samah, El Sayed, Ibrahim E.-T., El-Bahnsawye, Mohamed, Bayomi, Asmaa I., Samaka, Rehab M., Shaban, Elkhabiry, Elmongy, Elshaymaa I., El-Masry, Thanaa A., Ahmed, Hytham M. A., Attallah, Nashwah G. M.
Format: Artigo
Language:Inglês
Published: MDPI 2021
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7867085/
https://ncbi.nlm.nih.gov/pubmed/33535575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules26030754
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