Genome-wide detection of cytosine methylation by single molecule real-time sequencing

5-Methylcytosine (5mC) is an important type of epigenetic modification. Bisulfite sequencing (BS-seq) has limitations, such as severe DNA degradation. Using single molecule real-time sequencing, we developed a methodology to directly examine 5mC. This approach holistically examined kinetic signals o...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Tse, O. Y. Olivia, Jiang, Peiyong, Cheng, Suk Hang, Peng, Wenlei, Shang, Huimin, Wong, John, Chan, Stephen L., Poon, Liona C. Y., Leung, Tak Y., Chan, K. C. Allen, Chiu, Rossa W. K., Lo, Y. M. Dennis
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2021
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7865158/
https://ncbi.nlm.nih.gov/pubmed/33495335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2019768118
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