Size-tagged preferred ends in maternal plasma DNA shed light on the production mechanism and show utility in noninvasive prenatal testing

Cell-free DNA in human plasma is nonrandomly fragmented and reflects genomewide nucleosomal organization. Previous studies had demonstrated tissue-specific preferred end sites in plasma DNA of pregnant women. In this study, we performed integrative analysis of preferred end sites with the size chara...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Sun, Kun, Jiang, Peiyong, Wong, Ada I. C., Cheng, Yvonne K. Y., Cheng, Suk Hang, Zhang, Haiqiang, Chan, K. C. Allen, Leung, Tak Y., Chiu, Rossa W. K., Lo, Y. M. Dennis
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2018
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PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5984542/
https://ncbi.nlm.nih.gov/pubmed/29760053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1804134115
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