Genome-wide detection of cytosine methylation by single molecule real-time sequencing

5-Methylcytosine (5mC) is an important type of epigenetic modification. Bisulfite sequencing (BS-seq) has limitations, such as severe DNA degradation. Using single molecule real-time sequencing, we developed a methodology to directly examine 5mC. This approach holistically examined kinetic signals o...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Tse, O. Y. Olivia, Jiang, Peiyong, Cheng, Suk Hang, Peng, Wenlei, Shang, Huimin, Wong, John, Chan, Stephen L., Poon, Liona C. Y., Leung, Tak Y., Chan, K. C. Allen, Chiu, Rossa W. K., Lo, Y. M. Dennis
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2021
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7865158/
https://ncbi.nlm.nih.gov/pubmed/33495335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2019768118
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