SIRT7-dependent deacetylation of NPM promotes p53 stabilization following UV-induced genotoxic stress

Adaptation to different forms of environmental stress is crucial for maintaining essential cellular functions and survival. The nucleolus plays a decisive role as a signaling hub for coordinating cellular responses to various extrinsic and intrinsic cues. p53 levels are normally kept low in unstress...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Ianni, Alessandro, Kumari, Poonam, Tarighi, Shahriar, Simonet, Nicolas G., Popescu, Daniela, Guenther, Stefan, Hölper, Soraya, Schmidt, Andreas, Smolka, Christian, Yue, Shijing, Krüger, Marcus, Fiorillo, Claudia, Vaquero, Alejandro, Bober, Eva, Braun, Thomas
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2021
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7865150/
https://ncbi.nlm.nih.gov/pubmed/33495326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2015339118
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