Sirt7 promotes adipogenesis in the mouse by inhibiting autocatalytic activation of Sirt1

Sirtuins (Sirt1–Sirt7) are NAD(+)-dependent protein deacetylases/ADP ribosyltransferases, which play decisive roles in chromatin silencing, cell cycle regulation, cellular differentiation, and metabolism. Different sirtuins control similar cellular processes, suggesting a coordinated mode of action...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Fang, Jian, Ianni, Alessandro, Smolka, Christian, Vakhrusheva, Olesya, Nolte, Hendrik, Krüger, Marcus, Wietelmann, Astrid, Simonet, Nicolas G., Adrian-Segarra, Juan M., Vaquero, Alejandro, Braun, Thomas, Bober, Eva
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2017
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PNAS Plus
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5635888/
https://ncbi.nlm.nih.gov/pubmed/28923965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1706945114
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