Genomic evolution of antibiotic resistance is contingent on genetic background following a long-term experiment with Escherichia coli

Antibiotic resistance is a growing health concern. Efforts to control resistance would benefit from an improved ability to forecast when and how it will evolve. Epistatic interactions between mutations can promote divergent evolutionary trajectories, which complicates our ability to predict evolutio...

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Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Card, Kyle J., Thomas, Misty D., Graves, Joseph L., Barrick, Jeffrey E., Lenski, Richard E.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2021
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7865137/
https://ncbi.nlm.nih.gov/pubmed/33441451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2016886118
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