Plk1, upregulated by HIF-2, mediates metastasis and drug resistance of clear cell renal cell carcinoma

Polo-like kinase 1 (Plk1) expression is inversely correlated with survival advantages in many cancers. However, molecular mechanisms that underlie Plk1 expression are poorly understood. Here, we uncover a hypoxia-regulated mechanism of Plk1-mediated cancer metastasis and drug resistance. We demonstr...

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Pubblicato in:Commun Biol
Autori principali: Dufies, Maeva, Verbiest, Annelies, Cooley, Lindsay S., Ndiaye, Papa Diogop, He, Xingkang, Nottet, Nicolas, Souleyreau, Wilfried, Hagege, Anais, Torrino, Stephanie, Parola, Julien, Giuliano, Sandy, Borchiellini, Delphine, Schiappa, Renaud, Mograbi, Baharia, Zucman-Rossi, Jessica, Bensalah, Karim, Ravaud, Alain, Auberger, Patrick, Bikfalvi, Andréas, Chamorey, Emmanuel, Rioux-Leclercq, Nathalie, Mazure, Nathalie M., Beuselinck, Benoit, Cao, Yihai, Bernhard, Jean Christophe, Ambrosetti, Damien, Pagès, Gilles
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7865059/
https://ncbi.nlm.nih.gov/pubmed/33547392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-021-01653-w
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