Structure and binding properties of Pangolin-CoV spike glycoprotein inform the evolution of SARS-CoV-2

Coronaviruses of bats and pangolins have been implicated in the origin and evolution of the pandemic SARS-CoV-2. We show that spikes from Guangdong Pangolin-CoVs, closely related to SARS-CoV-2, bind strongly to human and pangolin ACE2 receptors. We also report the cryo-EM structure of a Pangolin-CoV...

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Publicado no:Nat Commun
Main Authors: Wrobel, Antoni G., Benton, Donald J., Xu, Pengqi, Calder, Lesley J., Borg, Annabel, Roustan, Chloë, Martin, Stephen R., Rosenthal, Peter B., Skehel, John J., Gamblin, Steven J.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7864994/
https://ncbi.nlm.nih.gov/pubmed/33547281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21006-9
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