Crystal structure of the human PRPK–TPRKB complex

Mutations of the p53-related protein kinase (PRPK) and TP53RK-binding protein (TPRKB) cause Galloway-Mowat syndrome (GAMOS) and are found in various human cancers. We have previously shown that small compounds targeting PRPK showed anti-cancer activity against colon and skin cancer. Here we present...

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Udgivet i:Commun Biol
Main Authors: Li, Jian, Ma, Xinli, Banerjee, Surajit, Chen, Hanyong, Ma, Weiya, Bode, Ann M., Dong, Zigang
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7864929/
https://ncbi.nlm.nih.gov/pubmed/33547416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-021-01683-4
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