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Pathological conformations of disease mutant Ryanodine Receptors revealed by cryo-EM
Ryanodine Receptors (RyRs) are massive channels that release Ca(2+) from the endoplasmic and sarcoplasmic reticulum. Hundreds of mutations are linked to malignant hyperthermia (MH), myopathies, and arrhythmias. Here, we explore the first MH mutation identified in humans by providing cryo-EM snapshot...
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| Publicado no: | Nat Commun |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7864917/ https://ncbi.nlm.nih.gov/pubmed/33547325 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21141-3 |
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