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NMDA receptors require multiple pre-opening gating steps for efficient synaptic activity
NMDA receptors (NMDAR) are glutamate-gated ion channels that mediate fast excitatory synaptic transmission in the nervous system. Applying glutamate to outside-out patches containing a single NMDAR, we find that agonist-bound receptors transition to the open state via two conformations, an ‘unconstr...
Enregistré dans:
| Publié dans: | Neuron |
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| Auteurs principaux: | , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2020
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7864875/ https://ncbi.nlm.nih.gov/pubmed/33264592 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2020.11.009 |
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