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Specific Sites within the Ligand-Binding Domain and Ion Channel Linkers Modulate NMDA Receptor Gating

Gating in the NMDA receptor is initiated in the extracellular ligand-binding domain (LBD) and is ultimately propagated via three linkers—S1-M1, M3-S2, and S2-M4—to the ion channel. M3-S2 directly couples LBD movements into channel gating, but the functional and structural contributions of S1-M1 and...

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Detalhes bibliográficos
Main Authors: Talukder, Iehab, Borker, Priya, Wollmuth, Lonnie P.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3207320/
https://ncbi.nlm.nih.gov/pubmed/20810899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5382-09.2010
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