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NMDA receptors require multiple pre-opening gating steps for efficient synaptic activity

NMDA receptors (NMDAR) are glutamate-gated ion channels that mediate fast excitatory synaptic transmission in the nervous system. Applying glutamate to outside-out patches containing a single NMDAR, we find that agonist-bound receptors transition to the open state via two conformations, an ‘unconstr...

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Detalhes bibliográficos
Publicado no:Neuron
Main Authors: Amin, Johansen, Gochman, Aaron, He, Miaomiao, Certain, Noele, Wollmuth, Lonnie P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7864875/
https://ncbi.nlm.nih.gov/pubmed/33264592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2020.11.009
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