Nitric oxide prevents aortic valve calcification by S-nitrosylation of USP9X to activate NOTCH signaling

Calcific aortic valve disease (CAVD) is an increasingly prevalent condition, and endothelial dysfunction is implicated in its etiology. We previously identified nitric oxide (NO) as a calcification inhibitor by its activation of NOTCH1, which is genetically linked to human CAVD. Here, we show NO res...

Полное описание

Сохранить в:
Библиографические подробности
Опубликовано в: :Sci Adv
Главные авторы: Majumdar, Uddalak, Manivannan, Sathiyanarayanan, Basu, Madhumita, Ueyama, Yukie, Blaser, Mark C., Cameron, Emily, McDermott, Michael R., Lincoln, Joy, Cole, Susan E., Wood, Stephen, Aikawa, Elena, Lilly, Brenda, Garg, Vidu
Формат: Artigo
Язык:Inglês
Опубликовано: American Association for the Advancement of Science 2021
Предметы:
Research Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7864581/
https://ncbi.nlm.nih.gov/pubmed/33547080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abe3706
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы