Nitric oxide prevents aortic valve calcification by S-nitrosylation of USP9X to activate NOTCH signaling

Calcific aortic valve disease (CAVD) is an increasingly prevalent condition, and endothelial dysfunction is implicated in its etiology. We previously identified nitric oxide (NO) as a calcification inhibitor by its activation of NOTCH1, which is genetically linked to human CAVD. Here, we show NO res...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Sci Adv
Päätekijät: Majumdar, Uddalak, Manivannan, Sathiyanarayanan, Basu, Madhumita, Ueyama, Yukie, Blaser, Mark C., Cameron, Emily, McDermott, Michael R., Lincoln, Joy, Cole, Susan E., Wood, Stephen, Aikawa, Elena, Lilly, Brenda, Garg, Vidu
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Association for the Advancement of Science 2021
Aiheet:
Research Articles
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7864581/
https://ncbi.nlm.nih.gov/pubmed/33547080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abe3706
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