Molecular basis for histone H3 “K4me3-K9me3/2” methylation pattern readout by Spindlin1

Histone recognition by “reader” modules serves as a fundamental mechanism in epigenetic regulation. Previous studies have shown that Spindlin1 is a reader of histone H3K4me3 as well as “K4me3-R8me2a” and promotes transcription of rDNA or Wnt/TCF4 target genes. Here we show that Spindlin1 also acts a...

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Publicat a:J Biol Chem
Autors principals: Zhao, Fan, Liu, Yunan, Su, Xiaonan, Lee, Ji-Eun, Song, Yutong, Wang, Daliang, Ge, Kai, Gao, Juntao, Zhang, Michael Q., Li, Haitao
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2021
Matèries:
Molecular Biophysics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7864079/
https://ncbi.nlm.nih.gov/pubmed/32994220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.013649
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