Leptin modulates pancreatic β-cell membrane potential through Src kinase–mediated phosphorylation of NMDA receptors

The adipocyte-derived hormone leptin increases trafficking of K(ATP) and Kv2.1 channels to the pancreatic β-cell surface, resulting in membrane hyperpolarization and suppression of insulin secretion. We have previously shown that this effect of leptin is mediated by the NMDA subtype of glutamate rec...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Biol Chem
Prif Awduron: Cochrane, Veronica A., Wu, Yi, Yang, Zhongying, ElSheikh, Assmaa, Dunford, Jeremy, Kievit, Paul, Fortin, Dale A., Shyng, Show-Ling
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2020
Pynciau:
Signal Transduction
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7863909/
https://ncbi.nlm.nih.gov/pubmed/33037073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.015489
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