Leptin modulates pancreatic β-cell membrane potential through Src kinase–mediated phosphorylation of NMDA receptors

The adipocyte-derived hormone leptin increases trafficking of K(ATP) and Kv2.1 channels to the pancreatic β-cell surface, resulting in membrane hyperpolarization and suppression of insulin secretion. We have previously shown that this effect of leptin is mediated by the NMDA subtype of glutamate rec...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Principais autores: Cochrane, Veronica A., Wu, Yi, Yang, Zhongying, ElSheikh, Assmaa, Dunford, Jeremy, Kievit, Paul, Fortin, Dale A., Shyng, Show-Ling
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2020
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7863909/
https://ncbi.nlm.nih.gov/pubmed/33037073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.015489
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