Microtubule affinity–regulating kinase 4 with an Alzheimer's disease-related mutation promotes tau accumulation and exacerbates neurodegeneration

Accumulation of the microtubule-associated protein tau is associated with Alzheimer's disease (AD). In AD brain, tau is abnormally phosphorylated at many sites, and phosphorylation at Ser-262 and Ser-356 plays critical roles in tau accumulation and toxicity. Microtubule affinity–regulating kina...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Oba, Toshiya, Saito, Taro, Asada, Akiko, Shimizu, Sawako, Iijima, Koichi M., Ando, Kanae
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2020
Subjects:
Molecular Bases of Disease
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7863894/
https://ncbi.nlm.nih.gov/pubmed/33020179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.014420
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