Genetic evidence for partial redundancy between the arginine methyltransferases CARM1 and PRMT6

CARM1 is a protein arginine methyltransferase (PRMT) that acts as a coactivator in a number of transcriptional programs. CARM1 orchestrates this coactivator activity in part by depositing the H3R17me2a histone mark in the vicinity of gene promoters that it regulates. However, the gross levels of H3R...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Cheng, Donghang, Gao, Guozhen, Di Lorenzo, Alessandra, Jayne, Sandrine, Hottiger, Michael O., Richard, Stephane, Bedford, Mark T.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2020
Subjects:
Gene Regulation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7863876/
https://ncbi.nlm.nih.gov/pubmed/33008887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.014704
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