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Structural and biochemical evaluation of bisubstrate inhibitors of protein arginine N-methyltransferases PRMT1 and CARM1 (PRMT4)

Attenuating the function of protein arginine methyltransferases (PRMTs) is an objective for the investigation and treatment of several diseases including cardiovascular disease and cancer. Bisubstrate inhibitors that simultaneously target binding sites for arginine substrate and the cofactor (S-aden...

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Detalhes bibliográficos
Publicado no:Biochem J
Main Authors: Gunnell, Emma A., Al-Noori, Alaa, Muhsen, Usama, Davies, Clare C., Dowden, James, Dreveny, Ingrid
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7054760/
https://ncbi.nlm.nih.gov/pubmed/32011657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BCJ20190826
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