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Brd4 regulates NLRC4 inflammasome activation by facilitating IRF8-mediated transcription of Naips
NLRC4 inflammasome activation and the subsequent maturation of IL-1β and IL-18 are critical for protection against infection by bacterial pathogens. The epigenetic regulator Brd4 has emerged as a key player in inflammation by regulating the expression of inflammatory cytokines. However, whether Brd4...
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| Veröffentlicht in: | J Cell Biol |
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| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Rockefeller University Press
2021
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7863722/ https://ncbi.nlm.nih.gov/pubmed/33535228 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.202005148 |
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