NAMPT/SIRT2-mediated inhibition of the p53-p21 signaling pathway is indispensable for maintenance and hematopoietic differentiation of human iPS cells

BACKGROUND: Nicotinamide phosphoribosyltransferase (NAMPT) regulates cellular functions through the protein deacetylation activity of nicotinamide adenine dinucleotide (NAD(+))-dependent sirtuins (SIRTs). SIRTs regulate functions of histones and none-histone proteins. The role of NAMPT/SIRT pathway...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Stem Cell Res Ther
Egile Nagusiak: Xu, Yun, Nasri, Masoud, Dannenmann, Benjamin, Mir, Perihan, Zahabi, Azadeh, Welte, Karl, Morishima, Tatsuya, Skokowa, Julia
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: BioMed Central 2021
Gaiak:
Research
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7863436/
https://ncbi.nlm.nih.gov/pubmed/33546767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13287-021-02144-9
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