LMO2 activation by deacetylation is indispensable for hematopoiesis and T-ALL leukemogenesis

Hematopoietic transcription factor LIM domain only 2 (LMO2), a member of the TAL1 transcriptional complex, plays an essential role during early hematopoiesis and is frequently activated in T-cell acute lymphoblastic leukemia (T-ALL) patients. Here, we demonstrate that LMO2 is activated by deacetylat...

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Bibliografische gegevens
Gepubliceerd in:Blood
Hoofdauteurs: Morishima, Tatsuya, Krahl, Ann-Christin, Nasri, Masoud, Xu, Yun, Aghaallaei, Narges, Findik, Betül, Klimiankou, Maksim, Ritter, Malte, Hartmann, Marcus D., Gloeckner, Christian Johannes, Stefanczyk, Sylwia, Lindner, Christian, Oswald, Benedikt, Bernhard, Regine, Hähnel, Karin, Hermanutz-Klein, Ursula, Ebinger, Martin, Handgretinger, Rupert, Casadei, Nicolas, Welte, Karl, Andre, Maya, Müller, Patrick, Bajoghli, Baubak, Skokowa, Julia
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society of Hematology 2019
Onderwerpen:
Lymphoid Neoplasia
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6888148/
https://ncbi.nlm.nih.gov/pubmed/31366618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019000095
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