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The G127V variant of the prion protein interferes with dimer formation in vitro but not in cellulo

Scrapie prion, PrP(Sc), formation is the central event of all types of transmissible spongiform encephalopathies (TSEs), while the pathway with possible intermediates and their mechanism of formation from the normal isoform of prion (PrP), remains not fully understood. Recently, the G127V variant of...

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Dettagli Bibliografici
Pubblicato in:Sci Rep
Autori principali: Sangeetham, Sudheer Babu, Engelke, Anna Dorothee, Fodor, Elfrieda, Krausz, Sarah Laura, Tatzelt, Jörg, Welker, Ervin
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2021
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7862613/
https://ncbi.nlm.nih.gov/pubmed/33542378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-82647-w
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