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Gating the pore of the calcium-activated chloride channel TMEM16A
The binding of cytoplasmic Ca(2+) to the anion-selective channel TMEM16A triggers a conformational change around its binding site that is coupled to the release of a gate at the constricted neck of an hourglass-shaped pore. By combining mutagenesis, electrophysiology, and cryo-electron microscopy, w...
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| Published in: | Nat Commun |
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| Main Authors: | , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Nature Publishing Group UK
2021
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7862301/ https://ncbi.nlm.nih.gov/pubmed/33542223 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-20787-9 |
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