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Gating the pore of the calcium-activated chloride channel TMEM16A

The binding of cytoplasmic Ca(2+) to the anion-selective channel TMEM16A triggers a conformational change around its binding site that is coupled to the release of a gate at the constricted neck of an hourglass-shaped pore. By combining mutagenesis, electrophysiology, and cryo-electron microscopy, w...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Lam, Andy K. M., Rheinberger, Jan, Paulino, Cristina, Dutzler, Raimund
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2021
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7862301/
https://ncbi.nlm.nih.gov/pubmed/33542223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-20787-9
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