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TonEBP regulates the hyperosmotic expression of aquaporin 1 and 5 in the intervertebral disc

The central region of the intervertebral disc (IVD) is rich in proteoglycans, leading to a hyperosmotic environment, which fluctuates with daily loading. The cells of the nucleus pulposus (NP cells) have adapted to this environment via the function of tonicity enhancer binding protein (TonEBP), and...

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Publicat a:Sci Rep
Autors principals: Snuggs, J. W., Tessier, S., Bunning, R. A. B., Shapiro, I. M., Risbud, M. V., Le Maitre, C. L.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2021
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7862284/
https://ncbi.nlm.nih.gov/pubmed/33542263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-81838-9
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