Arp2/3 inactivation causes intervertebral disc and cartilage degeneration with dysregulated TonEBP-mediated osmoadaptation

Extracellular matrix and osmolarity influence the development and homeostasis of skeletal tissues through Rho GTPase–mediated alteration of the actin cytoskeleton. This study investigated whether the actin-branching Arp2/3 complex, a downstream effector of the Rho GTPases Cdc42 and Rac1, plays a cri...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:JCI Insight
Autores principales: Tessier, Steven, Doolittle, Alexandra C., Sao, Kimheak, Rotty, Jeremy D., Bear, James E., Ulici, Veronica, Loeser, Richard F., Shapiro, Irving M., Diekman, Brian O., Risbud, Makarand V.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2020
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7101139/
https://ncbi.nlm.nih.gov/pubmed/31961823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.131382
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares