Arp2/3 inactivation causes intervertebral disc and cartilage degeneration with dysregulated TonEBP-mediated osmoadaptation

Extracellular matrix and osmolarity influence the development and homeostasis of skeletal tissues through Rho GTPase–mediated alteration of the actin cytoskeleton. This study investigated whether the actin-branching Arp2/3 complex, a downstream effector of the Rho GTPases Cdc42 and Rac1, plays a cri...

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Pubblicato in:JCI Insight
Autori principali: Tessier, Steven, Doolittle, Alexandra C., Sao, Kimheak, Rotty, Jeremy D., Bear, James E., Ulici, Veronica, Loeser, Richard F., Shapiro, Irving M., Diekman, Brian O., Risbud, Makarand V.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2020
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7101139/
https://ncbi.nlm.nih.gov/pubmed/31961823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.131382
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