NFAT5/TonEBP controls early acquisition of notochord phenotypic markers, collagen composition, and sonic hedgehog signaling during mouse intervertebral disc embryogenesis

High osmolarity, bound water, and hydrostatic pressure contribute to notochord mechanics and its morphogenesis into the nucleus pulposus (NP) compartment of the intervertebral disc. Indeed, the osmoadaptive transcription factor, nuclear factor of activated T-cells 5 (NFAT5 aka TonEBP), is robustly e...

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Publicado en:Dev Biol
Autores principales: Tessier, Steven, Madhu, Vedavathi, Johnson, Zariel I., Shapiro, Irving M., Risbud, Makarand V.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6842424/
https://ncbi.nlm.nih.gov/pubmed/31301300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2019.07.004
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