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Apigenin Alleviates Liver Fibrosis by Inhibiting Hepatic Stellate Cell Activation and Autophagy via TGF-β1/Smad3 and p38/PPARα Pathways

OBJECTIVE: The aim of this study is to confirm the hepatocellular protective functions of apigenin and the molecular mechanism on liver fibrosis in mice. METHODS: Carbon tetrachloride (CCl(4)) and bile duct ligature (BDL) mouse fibrosis models were used to investigate the effects of apigenin on live...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:PPAR Res
Prif Awduron: Ji, Jie, Yu, Qiang, Dai, Weiqi, Wu, Liwei, Feng, Jiao, Zheng, Yuanyuan, Li, Yan, Guo, Chuanyong
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Hindawi 2021
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7861947/
https://ncbi.nlm.nih.gov/pubmed/33574836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2021/6651839
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