Identification of a γc Receptor Antagonist that Prevents Reprogramming of Human Tissue-resident Cytotoxic T Cells by IL15 and IL21

BACKGROUND & AIMS: Gamma chain (γc) cytokines (interleukin 2 [IL2], IL4, IL7, IL9, IL15 and IL21) signal via a common γc receptor. IL2 regulates the immune response, whereas IL21 and IL15 contribute to development of autoimmune disorders, including celiac disease. We investigated whether BNZ-2,...

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Detalhes bibliográficos
Publicado no:Gastroenterology
Main Authors: Ciszewski, Cezary, Discepolo, Valentina, Pacis, Alain, Doerr, Nick, Tastet, Olivier, Mayassi, Toufic, Maglio, Mariantonia, Basheer, Asjad, Al-Mawsawi, Laith Q., Green, Peter, Auricchio, Renata, Troncone, Riccardo, Waldmann, Thomas A., Azimi, Nazli, Tagaya, Yutaka, Barreiro, Luis B., Jabri, Bana
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7861144/
https://ncbi.nlm.nih.gov/pubmed/31622625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2019.10.006
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