Results From a First-in-Human Study of BNZ-1, a Selective Multicytokine Inhibitor Targeting Members of the Common Gamma (γ c) Family of Cytokines

Pathologic roles of interleukin (IL)-2, IL-9, and IL-15, have been implicated in multiple T-cell malignancies and autoimmune diseases. BNZ-1 is a selective and simultaneous inhibitor of IL-2, IL-9, and IL-15, which targets the common gamma chain signaling receptor subunit. In this first-in-human stu...

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Detalhes bibliográficos
Publicado no:J Clin Pharmacol
Main Authors: Frohna, Paul A., Ratnayake, Anoshie, Doerr, Nick, Basheer, Asjad, Al-Mawsawi, Laith Q., Kim, Woo Jae, Zapata, Juan C., Wu, Xiaorong, Waldmann, Thomas A., Azimi, Nazli, Tagaya, Yutaka
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8317201/
https://ncbi.nlm.nih.gov/pubmed/31465127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcph.1522
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