Adenosine triphosphate binding cassette subfamily C member 1 (ABCC1) overexpression reduces APP processing and increases alpha- versus beta-secretase activity, in vitro

The organic anion transporter Adenosine triphosphate binding cassette subfamily C member 1 (ABCC1), also known as MRP1, has been demonstrated in murine models of Alzheimer's disease (AD) to export amyloid beta (Abeta) from the endothelial cells of the blood–brain barrier to the periphery, and t...

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Bibliographische Detailangaben
Veröffentlicht in:Biol Open
Hauptverfasser: Jepsen, Wayne M., De Both, Matthew, Siniard, Ashley L., Ramsey, Keri, Piras, Ignazio S., Naymik, Marcus, Henderson, Adrienne, Huentelman, Matthew J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Company of Biologists Ltd 2021
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7860133/
https://ncbi.nlm.nih.gov/pubmed/32878879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/bio.054627
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