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Adenosine triphosphate binding cassette subfamily C member 1 (ABCC1) overexpression reduces APP processing and increases alpha- versus beta-secretase activity, in vitro

The organic anion transporter Adenosine triphosphate binding cassette subfamily C member 1 (ABCC1), also known as MRP1, has been demonstrated in murine models of Alzheimer's disease (AD) to export amyloid beta (Abeta) from the endothelial cells of the blood–brain barrier to the periphery, and t...

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Библиографические подробности
Опубликовано в: :Biol Open
Главные авторы: Jepsen, Wayne M., De Both, Matthew, Siniard, Ashley L., Ramsey, Keri, Piras, Ignazio S., Naymik, Marcus, Henderson, Adrienne, Huentelman, Matthew J.
Формат: Artigo
Язык:Inglês
Опубликовано: The Company of Biologists Ltd 2021
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7860133/
https://ncbi.nlm.nih.gov/pubmed/32878879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/bio.054627
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