A stem cell based in vitro model of NAFLD enables the analysis of patient specific individual metabolic adaptations in response to a high fat diet and AdipoRon interference

Non-alcoholic fatty liver disease (NAFLD) is a multifactorial disease. Its development and progression depend on genetically predisposed susceptibility of the patient towards several ‘hits’ that induce fat storage first and later inflammation and fibrosis. Here, we differentiated induced pluripotent...

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Detalhes bibliográficos
Publicado no:Biol Open
Main Authors: Graffmann, Nina, Ncube, Audrey, Martins, Soraia, Fiszl, Aurelian Robert, Reuther, Philipp, Bohndorf, Martina, Wruck, Wasco, Beller, Mathias, Czekelius, Constantin, Adjaye, James
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists Ltd 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7860118/
https://ncbi.nlm.nih.gov/pubmed/33372064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/bio.054189
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