Safety, acceptability, and pharmacokinetics of a monoclonal antibody-based vaginal multipurpose prevention film (MB66): A Phase I randomized trial

BACKGROUND: MB66 film is a multipurpose prevention technology (MPT) product with monoclonal antibodies (mAbs) against HIV-1 (VRC01-N) and HSV-1 and 2 (HSV8-N). The mAbs were produced by transient expression in Nicotiana benthamiana (N). We conducted a Phase I clinical trial to assess the safety, pha...

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Dades bibliogràfiques
Publicat a:PLoS Med
Autors principals: Politch, Joseph A., Cu-Uvin, Susan, Moench, Thomas R., Tashima, Karen T., Marathe, Jai G., Guthrie, Kate M., Cabral, Howard, Nyhuis, Tara, Brennan, Miles, Zeitlin, Larry, Spiegel, Hans M. L., Mayer, Kenneth H., Whaley, Kevin J., Anderson, Deborah J.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2021
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7857576/
https://ncbi.nlm.nih.gov/pubmed/33534791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pmed.1003495
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