Safety, acceptability, and pharmacokinetics of a monoclonal antibody-based vaginal multipurpose prevention film (MB66): A Phase I randomized trial

BACKGROUND: MB66 film is a multipurpose prevention technology (MPT) product with monoclonal antibodies (mAbs) against HIV-1 (VRC01-N) and HSV-1 and 2 (HSV8-N). The mAbs were produced by transient expression in Nicotiana benthamiana (N). We conducted a Phase I clinical trial to assess the safety, pha...

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Опубликовано в: :PLoS Med
Главные авторы: Politch, Joseph A., Cu-Uvin, Susan, Moench, Thomas R., Tashima, Karen T., Marathe, Jai G., Guthrie, Kate M., Cabral, Howard, Nyhuis, Tara, Brennan, Miles, Zeitlin, Larry, Spiegel, Hans M. L., Mayer, Kenneth H., Whaley, Kevin J., Anderson, Deborah J.
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2021
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7857576/
https://ncbi.nlm.nih.gov/pubmed/33534791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pmed.1003495
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