Conformational dynamics during high-fidelity DNA replication and translocation defined using a DNA polymerase with a fluorescent artificial amino acid

We address the role of enzyme conformational dynamics in specificity for a high-fidelity DNA polymerase responsible for genome replication. We present the complete characterization of the conformational dynamics during the correct nucleotide incorporation forward and reverse reactions using stopped-...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Dangerfield, Tyler L., Johnson, Kenneth A.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2020
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7857513/
https://ncbi.nlm.nih.gov/pubmed/33273013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.016617
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