A feasibility study of combined epigenetic and vaccine therapy in advanced colorectal cancer with pharmacodynamic endpoint

Epigenetic therapies may modulate the tumor microenvironment. We evaluated the safety and optimal sequence of combination DNA methyltransferase inhibitor guadecitabine with a granulocyte macrophage-colony-stimulating-factor (GM-CSF) secreting colon cancer (CRC) vaccine (GVAX) using a primary endpoin...

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Detalhes bibliográficos
Publicado no:Clin Epigenetics
Main Authors: Bever, Katherine M., Thomas, Dwayne L., Zhang, Jiajia, Diaz Rivera, Ernie A., Rosner, Gary L., Zhu, Qingfeng, Nauroth, Julie M., Christmas, Brian, Thompson, Elizabeth D., Anders, Robert A., Judkins, Carol, Liu, Meizheng, Jaffee, Elizabeth M., Ahuja, Nita, Zheng, Lei, Azad, Nilofer S.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2021
Assuntos:
Short Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7856736/
https://ncbi.nlm.nih.gov/pubmed/33531075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-021-01014-8
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