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FANCD2 and HES1 suppress inflammation-induced PPAR(ɣ) to prevent haematopoietic stem cell exhaustion
The Fanconi anaemia protein FANCD2 suppresses PPAR(ɣ) to maintain haematopoietic stem cell’s (HSC) function; however, the underlying mechanism is not known. Here we show that FANCD2 acts in concert with the Notch target HES1 to suppress inflammation-induced PPAR(ɣ) in HSC maintenance. Loss of HES1 e...
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| Publicado no: | Br J Haematol |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7856217/ https://ncbi.nlm.nih.gov/pubmed/33222180 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bjh.17230 |
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