Positron Emission Tomography Imaging of Functional TGFβ Activity and Benefit of TGFβ Inhibition in Irradiated Intracranial Tumors

INTRODUCTION: Transforming growth factor β (TGFβ) promotes cell survival by endorsing DNA damage repair and mediates an immunosuppressive tumor microenvironment. Thus, TGFβ activation in response to radiation therapy is potentially targetable because it opposes therapeutic control. Strategies to ass...

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Publicado en:Int J Radiat Oncol Biol Phys
Autores principales: Gonzalez-Junca, Alba, Reiners, Oliver, Borrero-Garcia, Luis D., Beckford-Vera, Denis, Lazar, Ann A., Chou, William, Braunstein, Steve, VanBrocklin, Henry, Franc, Benjamin L., Barcellos-Hoff, Mary Helen
Formato: Artigo
Lenguaje:Inglês
Publicado: 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7856163/
https://ncbi.nlm.nih.gov/pubmed/33007434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijrobp.2020.09.043
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