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Quality-by-design in hot melt extrusion based amorphous solid dispersions: An industrial perspective on product development
An industrially feasible approach to overcome the solubility and bioavailability limitations of poorly soluble active pharmaceutical ingredients is the development of amorphous solid dispersions (ASDs) using hot-melt extrusion (HME) technique. The application of Quality by Design (QbD) had a profoun...
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| Udgivet i: | Eur J Pharm Sci |
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| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7855693/ https://ncbi.nlm.nih.gov/pubmed/33253883 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejps.2020.105655 |
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