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Quality-by-design in hot melt extrusion based amorphous solid dispersions: An industrial perspective on product development

An industrially feasible approach to overcome the solubility and bioavailability limitations of poorly soluble active pharmaceutical ingredients is the development of amorphous solid dispersions (ASDs) using hot-melt extrusion (HME) technique. The application of Quality by Design (QbD) had a profoun...

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Detalles Bibliográficos
Publicado en:Eur J Pharm Sci
Main Authors: Butreddy, Arun, Bandari, Suresh, Repka, Michael A.
Formato: Artigo
Idioma:Inglês
Publicado: 2020
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7855693/
https://ncbi.nlm.nih.gov/pubmed/33253883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejps.2020.105655
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