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HIV-Tat and Cocaine Impact Brain Energy Metabolism: Redox Modification and Mitochondrial Biogenesis Influence NRF Transcription-Mediated Neurodegeneration

HIV infection and drugs of abuse induce oxidative stress and redox imbalance, which cause neurodegeneration. The mechanisms by which HIV infection and cocaine consumption affect astrocyte energy metabolism, and how this leads to neurodegenerative dysfunction, remain poorly understood. Presently, we...

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Vydáno v:Mol Neurobiol
Hlavní autoři: Sivalingam, Kalaiselvi, Cirino, Thomas J., McLaughlin, Jay P., Samikkannu, Thangavel
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7855545/
https://ncbi.nlm.nih.gov/pubmed/32978730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12035-020-02131-w
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