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HIV-Tat and Cocaine Impact Brain Energy Metabolism: Redox Modification and Mitochondrial Biogenesis Influence NRF Transcription-Mediated Neurodegeneration

HIV infection and drugs of abuse induce oxidative stress and redox imbalance, which cause neurodegeneration. The mechanisms by which HIV infection and cocaine consumption affect astrocyte energy metabolism, and how this leads to neurodegenerative dysfunction, remain poorly understood. Presently, we...

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Bibliografische gegevens
Gepubliceerd in:Mol Neurobiol
Hoofdauteurs: Sivalingam, Kalaiselvi, Cirino, Thomas J., McLaughlin, Jay P., Samikkannu, Thangavel
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2020
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7855545/
https://ncbi.nlm.nih.gov/pubmed/32978730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12035-020-02131-w
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